"We have so many end points".
Given the difficulty in planning, setting up, securing, changing, and managing networks, reducing network complexity must be a mandate or we will never support that many end points.
In short, as we have learned from drug exposure studies, many end points in rodents can predict adverse outcomes in humans.
Future biomonitoring studies should make an effort to combine many end points, with emphasis on adducts, mutations, and constitutional metabolic factors.
Such data are required not only to evaluate any given model, but also to determine how many end points and/or models are necessary for predictive validity.
In a corollary study, many end points in the CBTS study were compared within one laboratory to an additional set of behavioral end points, named the Cincinnati Test protocol, using both methylmercury and -amphetamine (Vorhees et al. 1985a, 1985b).
Steroidogenesis and the hypothalamic-pituitary-gonadal axis appear to be important loci of phytoestrogen actions, but these inferences must be tentative because good dose-response data are not available for many end points.
For TCE, understanding metabolism is particularly important because, as discussed below, for many end points of observed toxicity, the active agent(s) is thought to be a metabolite(s) rather than the parent compound.
AhR activation plays a critical role in many end points of TCDD toxicity [Agency for Toxic Substances and Disease Registry (ATSDR) 1998; Hahn 2002; Mimura and Fujii-Kuriyama 2003; Van den Berg et al. 1998].
We conclude that the data requirements for many end points still have not been determined but depend on prioritization criteria and waiving practices that will be decided in the years to come.
"Eighty-five percent of PMNs [premanufacture notices, which must be submitted to the EPA at least 90 days before production of a new chemical begins] are submitted with no health data, and reliable models aren't available for many end points, particularly for long-term health effects other than cancer".
