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Sequence comparison of many effector genes shows evidence of accelerated evolution.
This is partly because IFN induces the expression of many effector genes, making the system rather complicated to dissect.
As opposed to Oomycete pathogen genomes in which many effector genes can be identified through conserved sequence motifs [ 29, 41], the use of conserved sequence motifs, such as the Y/F/WxC motif [ 42], has proven limited in revealing fungal effectors across lineages.
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We found that many RNAi effector genes are conserved in P. redivivus (Table S4 and Table S7).
PERK is a protein kinase that controls the expression of many UPR effector genes including Grp78 and Grp94 [ 17, 46, 47].
The central clock transcription factors that participate in their own cyclical expression and that of other core clock genes also either directly or indirectly drive daily oscillations in the expression of many downstream effector genes.
Particular focus has been devoted to parasites and pathogens because honey bees lack many immune effector genes [ 1] and may be particularly susceptible to disease because they experience a high contact rate between closely related nestmates within colonies [ 4] and in modern apiculture also between colonies and populations.
MiRNAs are known to regulate many developmental and effector genes at the posttranscriptional level [ 38, 42].
Many of the RXLR effector genes in the Hyaloperonospora arabidopsis genome also appear to occur in tandem arrays of diverse sizes (L. Baxter, personal communication).
Within this cluster of 58 genes we find many well-characterized immune effector genes, such as AMPs and those involved in ROS production; immune recognition proteins, such as peptidoglycan recognition proteins (PGRPs); thioester proteins; and scavenger receptors.
In our Cs study, this central radiation response factor and many of its downstream effector genes were activated at early times, and then inhibited at later times [ 24], giving a precedent for inhibition of p53 by internal radiation emitters.
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