Sentence examples for many effective compounds from inspiring English sources

Although the potency of these leads is above the nanomolar range the current the current paradigm of drug development suggests is desirable, many effective compounds are active in the micromolar range and uncritical application of the "nanomolar rule" could reject highly effective compounds [ 51].

Alternatively, MMPs are involved in many cellular functions and the side-effect profiles of compounds that would prevent joint destruction have meant that effective compounds are excluded during development.

Given that many men are unsuitable for chemotherapy, either because they are elderly or have comorbidities, there is still a pressing need to evaluate better-tolerated and more effective compounds and combinations for the treatment of this disease.

30– 32 Hence, there is a demand for alternative effective compounds.

Effective compounds from CI-B were further studied.

Streptomyces virginiae IBL14 is an effective degradative strain for many steroidal compounds and can also catalyze the C25 hydroxylation of diosgenin, the first-ever biotransformation found on the F-ring of diosgenin.

Many active compounds from soybeans were reported to be effective in preventing various inflammatory diseases and cancers [ 7].

However, widespread drug resistance has made many of these compounds less effective.

Although many of these compounds are effective in inhibiting STAT3 activation in whole cells, most also hit other targets in the cell.

Overall, these studies suggest that readthrough strategies can be effective to restore functional KMT2D and KDM6A activity, although testing additional mutations, many other compounds and different cell lines are mandatory to assess their potential therapeutic effectiveness.

Since QS systems control the expression of several virulence factors in many pathogens, compounds that block production of AHL signals or interfere with their activity may be effective anti-virulence agents.