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Many downstream type I interferon activated genes with anti-viral activity (PKR, Mx, ISG15 and OAS among others) were also up-regulated in response to ALVAC.
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Many downstream targets of TNF are also stimulated by type I IFN, as was demonstrated in a recent microarray study comparing cellular responses to treatment with each cytokine [35].
WT1 is known to be a potent transcriptional regulator of many downstream targets, and can thus function as a tumour suppressor or an oncogene depending on cell type and tumour entity.
The PCP and Wnt/Ca++ pathways have many downstream effectors, such as Ca++-sensitive enzymes, small GTPases, and JNK, which may vary in different cell types, but commonly regulate cell polarity and movement via changes in cytoskeletal dynamics [6], [24] [29].
Many downstream areas braced for expected record levels.
Turning shyness into a mental disorder has many downstream consequences.
As a result, in late May, the river dried up downstream of Al-Raqqa city, depriving many downstream towns of water.
There are many downstream services, of course, that can't be built into products.
We have noted that their priorities make them junior to many downstream appropriators including the State Line Canals.
The unanswered question is how many downstream purchases will these gurus influence.
One of the many downstream effects of climate change is ocean acidification.
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