Sentence examples for many downstream targets from inspiring English sources

Many downstream targets of TNF are also stimulated by type I IFN, as was demonstrated in a recent microarray study comparing cellular responses to treatment with each cytokine [35].

Phosphorylated Akt activates many downstream targets, including mTOR, and is thought to play a role in tumour progression.

HGF/c-Met signalling operates through many downstream targets, including PI3K/AKT and Notch in myocardium [8].

Since EGR2 is a regulator of many neurologically relevant genes, disruption of normal EGR2 expression has the potential to influence many downstream targets.

After MTA proteins were found to be a component of nucleosome remodeling and the deacetylation (NuRD) complex, many downstream targets were discovered.

Activated Akt can phosphorylate many downstream targets (e.g., Bad, Bax, and caspase-9) and suppress proapoptotic transcription factors (e.g., FoxO and p53) [ 10– 13].

It has been established that altered DNA methylation at critical regions of a master regulatory gene may exert profound effects on the expression of many downstream target genes (Lukens and Zhan 2007; Chinnusamy and Zhu 2009; Doerfler 2011).

The reduced expression of SP1 family transcription factors may result in aberrant expression of many downstream target genes which contribute to the pathophysiology of schizophrenia and related disorders.

Many downstream target genes of the UPR are co-regulated by IRE1α, PERK, and ATF6α, ensuring the redundancy and robustness of this adaptive response.

Although the expression of NF-kB was not altered, the expression levels of many downstream target genes of NF-kB were up-modulated in patients in cluster B, strongly indicating that transcriptional activity of NF-kB is high in cluster B and might be responsible for the poorer prognosis of these patients.

Many downstream target proteins are then activated through Akt- and GSK-3 β-mediated phosphorylation.