Sentence examples for many downstream target from inspiring English sources

It has been established that altered DNA methylation at critical regions of a master regulatory gene may exert profound effects on the expression of many downstream target genes (Lukens and Zhan 2007; Chinnusamy and Zhu 2009; Doerfler 2011).

The reduced expression of SP1 family transcription factors may result in aberrant expression of many downstream target genes which contribute to the pathophysiology of schizophrenia and related disorders.

Many downstream target genes of the UPR are co-regulated by IRE1α, PERK, and ATF6α, ensuring the redundancy and robustness of this adaptive response.

Although the expression of NF-kB was not altered, the expression levels of many downstream target genes of NF-kB were up-modulated in patients in cluster B, strongly indicating that transcriptional activity of NF-kB is high in cluster B and might be responsible for the poorer prognosis of these patients.

Many downstream target proteins are then activated through Akt- and GSK-3 β-mediated phosphorylation.

Similarly MAPKs are also contain short docking site that recognizes many downstream target proteins by utilizing the same strategy.

The PRC2 complex serves as a central mediator between proliferation and differentiation and understanding the functions of its many downstream targets offers new insight into how skeletal muscle grows and repairs.

Many downstream targets of TNF are also stimulated by type I IFN, as was demonstrated in a recent microarray study comparing cellular responses to treatment with each cytokine [35].

HGF/c-Met signalling operates through many downstream targets, including PI3K/AKT and Notch in myocardium [8].

Phosphorylated Akt activates many downstream targets, including mTOR, and is thought to play a role in tumour progression.

CRK-I/II interact with many downstream targets including: son of seven less homolog (SOS1); downstream of CRK (DOCK1) and stress activated protein kinase (JNK1).