Sentence examples for many downstream responses from inspiring English sources

The specific role of hemorrhage is difficult to evaluate in trauma-induced lesions, because mechanical injury initiates many downstream responses.

However, examples such as the submergence-tolerance OsSUB1A gene (Xu et al. 2006; Fukao and Bailey-Serres 2008) and Pup1 (Gamuyao et al. 2012) demonstrate that a single gene can modify many downstream responses without affecting plant performance under non-stressed conditions (Mackill et al. 2012).

An elegant biochemical study of the contribution of Raf-1 and B-Raf to B-cell receptor (BCR) signalling showed that Raf-1 and B-Raf are activated with different kinetics and cooperate in many downstream responses (Brummer et al, 2002).

We thus identified several interferon signaling network members as the most significantly activated upstream regulators (IFNα, IFNα2, IFNβ, IFNγ, IFNL1, IRF1) (Table  3); together, these factors regulate many downstream immune response genes.

Since all processes of amphibian intestinal remodeling are dependent on TH and many downstream TH response genes have been identified in the Xenopus laevis intestine [ 10], the Xenopus model provides an excellent opportunity to elucidate such conserved mechanisms at the molecular level.

The reasons for this are unknown but may relate to the complexities of the pathways regulated by p38, which is at the hub of the stress-induced response and regulates many downstream kinases and cellular processes [6].

Among AKTs downstream targets is the tumor suppressor gene TP53 (HGNC:11998), a transcription factor that integrates information from many different types of cellular stress, and execute downstream responses appropriate for the given input [16].

ATM mediates cellular responses to DNA damage by phosphorylating its many downstream targets, thereby activating cell cycle checkpoints and causing cell cycle arrest to facilitate DNA damage repair and DNA recombination.

PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR).

Many downstream targets of TNF are also stimulated by type I IFN, as was demonstrated in a recent microarray study comparing cellular responses to treatment with each cytokine [35].

Many downstream areas braced for expected record levels.