Sentence examples for many downstream genes from inspiring English sources

Until now, the resulting concepts and strategies for engineering salinity stress tolerance in their majority targeted single genes in biochemical pathways, which represent end points of response cascades, but engineering of upstream master switches that regulate the activity of many downstream genes and proteins is increasingly attempted.

Given the high level of expression and wide distribution of atoh8 during early embryonic zebrafish development, it would not be surprising if this gene is involved in regulation of the expression of many downstream genes and also has an effect on the formation of many other organs besides retina and somites.

NF-κB activation promotes the transcription of many downstream genes in the signaling cascade [ 41].

The demethylation of hydralazine might modulate many downstream genes such as Hif1α and possibly cause additional adverse effects.

Many downstream genes of the AREB family are expressed under dehydration stress in the areb1 areb2 abf3 triple mutant.

Activation of NLR signaling networks results in the expression of many downstream genes including cytokines [ 17– 17].

However, many downstream gene targets of E were unlikely to have been discovered using this approach.

Each manipulated TF modifies the expression of many downstream target genes, including other TFs, which can in turn activate or repress genes even farther downstream.

It has been established that altered DNA methylation at critical regions of a master regulatory gene may exert profound effects on the expression of many downstream target genes (Lukens and Zhan 2007; Chinnusamy and Zhu 2009; Doerfler 2011).

The central clock transcription factors that participate in their own cyclical expression and that of other core clock genes also either directly or indirectly drive daily oscillations in the expression of many downstream effector genes.

The reduced expression of SP1 family transcription factors may result in aberrant expression of many downstream target genes which contribute to the pathophysiology of schizophrenia and related disorders.