Sentence examples for many downstream functions from inspiring English sources

Additionally, mouse S100A7/psoriasin possesses a putative Jab1 binding motif that mediates many downstream functions of the human S100A7 gene.

By eliciting, enhancing, or inhibiting estrogenic signaling, they may interfere with physiological estrogenic signals, affecting many downstream functions.

Subsequently, Akt phosphorylates and regulates the function of many downstream cellular proteins involved in the processes of apoptosis, proliferation, and transformation (Alessi et al. 1997; Franke et al. 2003).

WT1 is known to be a potent transcriptional regulator of many downstream targets, and can thus function as a tumour suppressor or an oncogene depending on cell type and tumour entity.

Adipose NADPH oxidase-derived reactive oxygen species (ROS) function as important intracellular second messengers to activate many downstream signaling molecules that modulate endothelial function, pathological growth and migration of vascular cells, expression of pro-inflammatory mediators and modification of extracellular matrix [ 36– 36].

This pathway is highly expressed in MM and shares many downstream targets with the Pim kinases which function in parallel, though independently.

As Bax and Bak are responsible for processing a variety of apoptotic signals and trigger many downstream factors, it will be interesting to study their regulatory function in self-renewal in other contexts and the exact molecular mechanisms.

ATM phosphorylates more than 700 proteins, including many downstream kinases (Matsuoka et al. 2007) demonstrating a broad range of functions.

miR-34a functions as a tumor-suppressor miRNA, and can target many downstream genes in the development and progression of carcinogenesis.

Although the mechanism by which they achieve these functions is unclear, the CPC is important for recruitment of many downstream effectors.

Cells in other assays of SCAR/WAVE function are unlikely to have been exposed to as many apoptotic corpses as hemocytes are during development; alternatively upstream roles in phagocytosis may have hidden downstream functions of SCAR in processing.