Sentence examples for many downstream factors from inspiring English sources
In the complex molecular infrastructure that underlies the mechanisms of activation and transduction, ERK orchestrates a series of signalling events that result in the recruitment of many downstream factors, including kinases, transcription factors, and other proteins.
The Akt activates many downstream factors, including mTOR, which in turn activates 4EBP1 and p70S6K1.
Slit2 is one of the many downstream factors of β-catenin.
The interaction network of BraDofs showed a very complicated correlation with other genes in Chinese cabbage, which may indicate BraDof genes involve in many fundamental mechanisms by regulating many downstream factors or being regulated by many upstream genes.
As Bax and Bak are responsible for processing a variety of apoptotic signals and trigger many downstream factors, it will be interesting to study their regulatory function in self-renewal in other contexts and the exact molecular mechanisms.
Patient 1 has tumor repressive transitions in the APC gene and tumor activating transitions in Axin, PP2A, β-catenin and in many downstream factors along the WNT-signalling pathway affecting transcription, cell cycle and CRC development, especially within the TCF/ LEF family [ 41, 42].
Analyses of the putative target genes bound and regulated by these factors suggest that Ubx regulates many downstream transcription factors and developmental pathways in the haltere and T3 leg.
Another consideration is that while PI3Ks are important regulators of Foxo transcription factors, many downstream signaling pathways controlled by PI3Ks regulate post-transcriptional, metabolic, cytoskeletal and other relevant cellular events [41].
We thus identified several interferon signaling network members as the most significantly activated upstream regulators (IFNα, IFNα2, IFNβ, IFNγ, IFNL1, IRF1) (Table 3); together, these factors regulate many downstream immune response genes.
The tumor suppressor gene p53 encodes a transcription factor that mediates many downstream effects such as growth arrest and apoptosis through activation or repression of its target genes [ 46].
This could lead to many downstream transcriptional effects since Esr1 is a transcription factor that has been shown to interact with 18 different nuclear receptors (Nuclear Receptor Signaling Atlas, http://www.nursa.org).
