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One of the many downstream effects of climate change is ocean acidification.
Δ6FAD is important for the modification of polyunsaturated fatty acids (PUFAs) in many vertebrates (Zheng et al., 2004), and any reduction can have many downstream effects.
Many downstream effects of increased [Ca2+]i have been reported that may modify the progression of AD, including Ca2+-dependent activation of the calpain family of proteases.
GTP-bound Rho proteins induce many downstream effects through interactions with an array of effector proteins, including protein kinases, lipid kinases, phospholipases, and various adaptor proteins.
Randomization to the intensive arm was associated with or led to many downstream effects, such as higher rates of severe hypoglycemia; more frequent use of insulin, thiazolidinediones, other drugs, and drug combinations; and greater weight gain.
The tumor suppressor gene p53 encodes a transcription factor that mediates many downstream effects such as growth arrest and apoptosis through activation or repression of its target genes [ 46].
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This could lead to many downstream transcriptional effects since Esr1 is a transcription factor that has been shown to interact with 18 different nuclear receptors (Nuclear Receptor Signaling Atlas, http://www.nursa.org).
Finally, hypoxia in airway epithelium is known to result in many major downstream effects mediated through HIF1-α, and Mo et al. offers the first investigation into the potential roles of HIF1-α in allergic rhinitis.
The ArtA protein has many downstream targets effecting cell shape and surface decoration, indicating that it could be a regulatory component of biofilm formation and/or related systems [ 94].
The combined effects of these issues, which essentially deny nationality to many Roma, have downstream effects upon the right to health.
Several pathways, involving many downstream proteins, mediate the effects of TGF- β1.
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many downstream factors
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many downstream kinases
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many downstream analyses
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many downstream genes
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