More than 300 substrates of CK2 have been discovered and is involved in many diverse pathways.
Figure 4 shows that many diverse pathways were temporally activated or repressed, according to the SST treatment.
Notably, it is increasingly evident that environmental agents may exert their carcinogenic effects through many diverse pathways, not only through somatic mutation but also epigenetic changes such as methylation, histone modification, miRNA etc [ 8].
The ability to approach metabolism as an integrator of many diverse signalling pathways, prompts consideration of the imaging and diagnostic studies that might track metabolic modulation.
Members of the FOX family are involved in many diverse developmental pathways, and mutations in FOXP2 cause a distinct form of developmental verbal dyspraxia in the KE family, as previously discussed (Lai et al. 2001).
In summary, the fact that the FEM algorithm has retrieved many diverse signalling pathways with important roles in breast cancer progressions attests to the power and usefulness of this algorithm.
For 'outside-in' signaling, integrin activation recruits a large variety of proteins that interface with the actin cytoskeleton and affect many diverse signaling pathways, including ILK-mediated phosphorylation of target genes, such as AKT.
WD40 gene family shows low level of sequence conservation with functional diversity in diverse pathways, and many WD40 proteins possess additional domains with other functional activities.
In the last decade, many diverse RNAi (RNA interference) pathways have been discovered that mediate gene silencing at epigenetic, transcriptional and post-transcriptional levels.
Helicases unwind nucleic acids and play many essential roles in diverse pathways involving the manipulation of DNA and RNA species, including DNA replication, recombination, repair, transcription, translation and RNA splicing.
cAMP is increasingly appreciated as an important regulator of diverse pathways in many bacteria.
