However we have previously collated and described many other diverse compounds active against Ebola in vitro as described in this manuscript.
Many structurally diverse compounds function through activation of the aryl hydrocarbon receptor (AhR) to contribute to the development of diseases (Poland et al. 1985; Safe 1986; Safe et al. 1985; Sato et al. 2008; Schmidt and Bradfield 1996; Swanson 2002; Van den Berg et al. 2006).
This leaves one to wonder, how many diverse conformers per compound might be necessary to saturate this coverage and moderate the effects of this sensitivity?
An over-abundance of P-glycoprotein (P-gp), the protein product of the MDR1 gene [1], leads to multidrug resistance (MDR), because cancer cells become able to efflux a number of structurally diverse compounds including many chemotherapy agents, such as paclitaxel [11], [12], doxorubicin [13], and vinblastine [14].
These enzymes are involved in the production of a range of diverse compounds, including many clinically useful antibiotics.
We then screened a library containing 2080 biologically active and structurally diverse compounds, including many FDA approved and currently marketed drugs.
The hERG channel is blocked by a plethora of structurally diverse compounds, including many marketed drugs, some of which, such as terfenadine and cisapride, have been withdrawn from the market due to this unwanted activity [ 1- 3].
Natural product researchers have developed many new techniques over the past few years for developing diverse compounds of biopotential.
This rich source of chemically diverse compounds was successfully exploited for the production of many anti-microbial and anti-cancer drugs in the first decades of antibiotic development but was then abandoned (Fischbach & Walsh, 2009).
