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The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Ubiquitination plays a key role in regulating many diverse cellular functions, predominantly by tagging proteins for destruction via either the proteasome or lysosome.
Since Cnn functions in many diverse cellular processes, it was assumed to be impossible to examine a specific developmental defect in the photoreceptor.
They play major roles in many diverse cellular processes [ 13- 17].
Members of the kinesin superfamily perform many diverse cellular functions such as transport of vesicles and organelles, spindle formation and elongation, chromosome segregation, microtubule dynamics and morphogenesis.
It is this PTM complexity that imparts the capacity to coactivators to regulate so many diverse cellular reactions, some of which even occur outside the nucleus [ 3, 7].
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Because the Akt pathway plays vital roles in controlling many diverse essential cellular processes, it is likely that drugs would only be tolerated if they modestly inhibit the Akt-signalling network.
PTEN is one of the most frequently lost tumor suppressors in human cancers and has been shown to have many diverse effects on cellular behavior, acting in many cell types to inhibit cellular survival, growth, and motility [1 3].
This can account for many of the diverse cellular phenotypes seen in this disease, including intracytoplasmic protein accumulation, mitochondrial dysfunction and increased apoptosis.
The transcriptomic content of LCLs includes many genes from diverse cellular pathways and has proven valuable for studying genome-wide individual differences in alternative mRNA splicing [ 60].
For example, the yeast Hsp90 chaperone HSP82 is considered to be a genetic capacitor genetically interacting with many (289) genes from diverse cellular processes, and may generically buffer phenotypic variation [24].
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