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The team, led by Marcelo Rivolta, took human embryonic stem cells, which can grow into many different tissue types, and transformed them with chemical growth factors into both early stage auditory neurons and sensory hair cells found in the cochlea – the spiral tube that forms part of the inner ear.
Like ESCs, iPSCs have the potential to differentiate into many different tissue cell types.
Xenogeneic and allogeneic ECM has been used as a bioscaffold for the reconstruction of many different tissue types in both pre-clinical and human clinical studies.
As ESCs are reliable and versatile for generating many different tissue cell types, it is an appealing option to generate a "universal" hESC line with significantly reduced expression of MHC molecules.
These attributes combine to allow MSC to reside in many different tissue types without disrupting the local microenvironment and, in some cases, responding to the local environment with appropriate protein secretion.
MSCs have been identified and propagated from many different tissue sources [21] [23].
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This modest overlap is probably due to the fact that the highly dynamic context of a developing embryo, in which many different tissue-specific enhancers and pathways might be active, differs from that of a tumor derived from one particular lineage.
Stem cells are found in many different tissues throughout the body.
The kind of disease that might be better treated in the germ line, if ethically acceptable, is cystic fibrosis, which affects many different tissues.
The growth of cells in the body is a closely controlled function, which, together with limited and regulated expression of various genes, gives rise to the many different tissues that constitute the whole organism.
Epithelial tissues are structured and highly organized monolayers of cells with many different tissue-specific functions.
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