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This is important to generate buzz ahead of the announcement and to ensure that many different target publications cover the story.
But unlike those and other detection schemes, Mirkin and colleagues say, the new approach should make it possible to detect many different target compounds simply by altering the sensing molecule.
The sum of random complex returns, Al,k, from many different target scatterers on target l are zero-mean, complex Gaussian with known variance 2 σ A, l 2 and follow the Swerling I model[25].
In the absence of TnsD and TnsE, transposition mediated by a hyperactive TnsABC* occurs into many different target sites with low selectivity [26].
Indeed a degree of energetic sub-optimality may be necessary, where single miRNA has to bind many different target sites in different mRNAs.
Thus, the ability to use the OPEN method to rapidly engineer ZFNs with both high activities and low toxicities for many different target sites should greatly enhance prospects for successfully using ZFNs to induce specific HR events in zebrafish.
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The use of smaller molecules (fragments) in the drug discovery process has led to success in delivering novel leads for many different targets.
In your book you talk a lot about how it's not all about racism, that the resentments of small-town America are broader, and have many different targets.
Gelatinases cleave many different targets (extracellular matrix, cytokines, growth factors, chemokines and cytokine/growth factor receptors) that in turn regulate key signaling pathways in cell growth, migration, invasion, inflammation and angiogenesis.
There is the SA-22 Greyhound, a mobile system with both surface-to-air (SAM) missiles and anti-aircraft guns, the SA-17 Grizzly, a medium-range missile capable of handling many different targets simultaneously, and the long-range SA-5 Gammon, which poses a threat to command-and-control aircraft and aerial tankers.
"There are so many different targeted applications to help people solve problems on a daily basis," she said in an interview — things like a solar-powered lantern that an Indian midwife can hang above the bed so that both of her hands are free, for example.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com