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Markers for many different stem cell populations have been elucidated, but challenges still remain.
Many different stem cell sources, including fetal tissue, umbilical cord, and adipose tissue are being investigated, with the majority of the trials currently underway involving MSCs from various sources[2].
This has led to the proposed use of histocompatible, patient-specific stem cells; however, the preparation of many different stem cell lines for clinical use is a daunting task.
Murine teeth can be regenerated using many different stem cells to collaboratively form dental structures in vivo [4], [5], [7].
However, it is well known that bone marrow is composed of many different stem cell populations, only a fraction of which are hematopoietic stem cells (HSC), and, only a fraction of these HSC are committed to the erythrocyte population.
The low oxygen consumption of glycolytic metabolism appears well matched to the physiological hypoxia of the niche in which many different stem cells reside (Burgess et al., 2014; Mohyeldin et al., 2010).
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Lastly, Wnt signalling stimulates the self-renewal of many different adult stem cell populations [ 7].
The body contains many different types of stem cells, such as neural stem cells, which go on to form the nervous system, and epithelial stem cells, which give rise to various types of surfaces in the body, such as the skin and the lining of the intestine.
CD133 is expressed in many different types of stem cells and is thought to be involved in the attachment of stem cells to their niche.
Whereas stem cells in the fetal forebrain undergo rapid division and are capable of generating many different cell types, stem cells in the adult forebrain divide less often and can generate only a few specific types of cell.
There are many different types of stem cell.
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