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Its enzymatic activity relies on the availability of ATP, inorganic phosphate, and NAD+ produced by glycolysis and respiratory chain controlling the mitochondrial redox status, the metabolite flux and many different signalling pathways, including amino acid synthesis15,19,20.
During the process of cerebral ischemia, many different signalling pathways are involved in the activation or suppression of mitophagy.
Depending on the type of cancer under investigation many different signalling molecules and pathways are believed to actively partake in the IL-24-mediated killing of target cells (for comprehensive reviews, see [34], [35]).
Interaction between many different signalling pathways is necessary to form a metazoan starting from a single egg cell.
There is a plethora of data implicating many different signalling pathways in preconditioning and the relevant role of each remains hotly debated (see [16,30,103 107]).
Granulocyte colony-stimulating factor is known to activate many different signalling pathways, but principal among these is the JAK2/STAT3 pathway (Ward, 2007).
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But receptors like Fat can respond to many different signals.
Mr. Nara's paintings send so many different signals that they're almost passive-aggressive.
The programmability of DNA will also allow probing the effect of many different signals independently, as well as their synergies.
Protein engineering approaches to optimize secretion often involve the screening of large libraries, e.g. comprising a target protein fused to many different signal peptides.
Many different signaling molecules that regulate integrin affinity have been described, but a pathway that connects agonist stimulation to talin binding and activation has not been mapped.
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Justyna Jupowicz-Kozak
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