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Using different synthesis strategies and functionalization moieties, it is possible to design nanocarriers with specific targeting and drug delivery abilities for many different pathological conditions.
Metabolic bone diseases result from many different pathological processes which have in common a deleterious effect on bone architecture and strength.
It should be pointed out that decreased levels of platelet serotonin have been reported in many different pathological or debilitating conditions, notably in psychiatric and neurologic diseases, and thus platelet serotonin levels in ALS, as observed decreased here, should not be considered as a specific biomarker of ALS.
Of these activated cells, macrophages play a central role in managing many different pathological immune phenomena such as the over-production of inflammatory mediators.
Uncontrolled lipid oxidation has been shown to be involved in the development of many different pathological conditions such as age-related diseases, malignancy, infective diseases, and injuries [ 1– 3].
We trust that the combination of the different therapeutic approaches discussed in this review will prove more efficient in curing or alleviating the many different pathological manifestations of LSDs.
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Of these activated cells, macrophages play a central role in managing many different immune pathological phenomena such as the over-production of pro-inflammatory cytokines and inflammatory mediators [ 2]. iNOS and COX-2 responsible for the elevated level of NO and prostaglandins, respectively, are well known key pro-inflammatory mediators in many diseases [ 3, 4].
Many degenerative diseases and normal aging lead to an inflammatory condition, thus this regulation of the immune response is important under many different kinds of pathological conditions.
MiRNAs modulate gene expression at the posttranscriptional level and can modulate many different cellular and pathological processes by fine tuning protein expression patterns[35].
Myeloid neoplasms and acute leukemia encompass many different clinical and pathological entities, some with unique genetic features and reflection on risk-stratification and appropriate therapy strategies.
As kinases have been related to many different types of pathological states, such as cardiovascular diseases, cancer, and neurodegenerative diseases [ 9, 10], a considerable amount of research is now devoted to finding drugs that target kinases [ 11].
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