Because many different atomic nuclei resonate at a characteristic radio frequency in a given magnetic field, NMR spectroscopy is now widely used to determine the molecular make-up of chemical compounds.In the late 1960s, Dr Damadian, at the time a physician at State University of New York's medical centre in Brooklyn, was among the first to contemplate using NMR to scan the human body for disease.
The EJC core is stably bound to the mRNA and serves as an anchoring platform for many different proteins in the nucleus and in the cytoplasm.
The first reports of actin inside the nucleus of a cell appeared forty years ago (LeStourgeon et al., 1975), and since that time, actin has been found in the nuclei of many different cell types, linked to a variety of nuclear processes (Pederson and Aebi, 2002).
To reflect its enrichment in the nucleus of many different cell types in different organisms and its homology to human NEAT1, we refer to the Neat1/ Vinc transcript as Neat1.
Neuromodulatory neurons reside in complex nuclei that harbour many different types of neurons, raising doubts about whether any recorded electrophysiological activity can really be related to particular neuromodulators.
All these in vivo observations are in favour of a model, in which these large multiprotein complexes are dynamically and probably constantly assembled and dissociated in the cell nucleus depending on many different cellular requirements.
We also see similar specialization in subcellular organelles where there is compartmentation of many different functions, e.g. the mitochondria, and the nucleus.
Many different histone methylations also show a progressive increase in transplanted nuclei.
The basal nuclei and thalamus are known to participate in many different neuronal pathways, with functions that are not just restricted to motor behaviour, but are also related to emotional, motivational, associative and cognitive abilities (Herrero et al., 2002).
This is the case for the sunflower protein HaWLIM1 that, for many different cell types, localizes either in the cytoplasm, in the nucleus, or in both.
