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Many authors have reported decreased ADC values for many different malignant tumors.
Elk-1 is associated with tumorigenesis of many different malignant diseases, such as cancer of the breast, colon, endometrium and HCC.
Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues.
The attribute of BST-2 that endows it the ability to simultaneously promote so many different malignant processes is yet to be discovered.
Also, DEX has been shown to induce resistance toward diverse other cytotoxic agents used in cancer therapy and also in many different malignant cell types in vitro (Rutz, 2002; Rutz and Herr, 2004).
CXCL12 can bind another chemokine receptor, such as CXCR7, which is present on the surface of many different malignant cell types (Burns et al, 2006), on tumour-associated blood vessels, but not on normal vasculature (Miao et al, 2007).
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Many different types of malignant tumors arise within the sinonasal cavities, constituting less than one percent of all malignant neoplasms.
PD-L1 has been described to be expressed on cancer cells in many different hematological malignancies, where it contributes to protection of the malignant cells from immune destruction.
Snail is one of the master regulators that promotes EMT and mediates invasiveness as well as metastasis in many different types of malignant tumors [ 23, 24].
In humans, it is expressed not only in immune cells but also in many different types of malignant cells, such as breast cancer (Gonzalez-Reyes et al. 2010) and melanoma cells (Salaun et al. 2007).
PGE2 is produced by many different cell types, including malignant cells, and is known to contribute to cellular immune suppression in cancer patients [4], [5].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com