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Synovitis due to many different inflammatory conditions (including rheumatoid arthritis) or even in late stage osteoarthritis commonly affects the knee joint.
NF-κB is a transcription factor involved in gene expression of many different inflammatory molecules whose function is crucial for microglial activation and induction of reactive astrogliosis.
Fusobacteriales have been implicated to play a role in many different inflammatory processes, including colonic inflammation [ 33- 35].
NSAIDs are frequently used as first-line agents for the symptomatic relief of many different inflammatory conditions.
Galectins are expressed by many different inflammatory cells and regulate the function of these cells (Rabinovich et al, 2002a).
Although inhibition of IFN-γ could have a therapeutic effect in many different inflammatory diseases, it may also promote survival of bacteria.
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Evidence for virus-like particle production has been obtained in samples from many different autoimmune, inflammatory, hematopoietic, or neoplastic diseases 38, which has been used to argue for a causal effect.
Human serum (a significant component of PL) contains many different anti-inflammatory proteins including alpha-2-macroglobulin, interleukin receptor antagonist, and tissue inhibitor of metalloproteinase (Chen et al. 2014; Villeneuve et al. 2009).
Indeed, recent studies on changes of gene expression in glia cells revealed that many different pro-inflammatory cytokines can induce mitochondrial injury [ 106].
Potentially, in the infected tissues many different types of inflammatory cells can produce these cytokines/chemokine including, but not limited to macrophages, DCs, and lymphocytes.
The FcγRs play important roles in the initiation and propagation of many different immunological and inflammatory processes.
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