Sentence examples for many developmental defects from inspiring English sources
This is also the stage at which many developmental defects originate.
Prenatal alcohol exposure produces many developmental defects of the central nervous system (CNS), such as in the corpus callosum (CC).
As a result, many developmental defects are observed, including neural crest cell death, the absence of limb buds and posterior branchial arches, small somites, and hindbrain segmentation defects, which have been known in general as VAD (vitamin A-deficiency syndrome) [47], [48], [49].
Misregulation of apoptosis is linked to many developmental defects and diseases such as tumour formation, autoimmune diseases and neurological disorders.
The Abl−/− mice are runt and suffer from many developmental defects that make them unsuitable for the study of stress-induced cell death.
It is therefore not surprising that deregulation of Wnt signaling pathway has been linked to many developmental defects in addition to many age-related diseases including osteoporosis and cancer (Clevers & Nusse, 2012).
One of the most surprising findings of recent years comes from animal studies that suggest that many genetic developmental defects, including those that affect neural plasticity, can largely or completely be reversed in adult life by reversing the biochemical defect (Ehninger et al., 2008); such findings indicate that therapy may be effective in cases where it had been thought not to be so.
Patients with Apert syndrome are characterized by premature fusion of the coronal suture(s) and severe craniofacial dysmorphology (Cohen and MacLean, 2000), but also exhibit many other developmental defects, including limb abnormalities, heart and lung defects, as well as neural malformations that could lead to cognitive impairment (Cohen and MacLean, 2000).
Therefore, in many cases, the developmental defects caused by a small molecule can be linked with high resolution to a specific genetic pathway known to cause the same defect.
Taken together, many CS-associated developmental defects have been accurately recapitulated in mice and zebrafish, but not yet in Drosophila.
In tomato, the diageotropica (dgt) mutant displays many auxin-related developmental defects and fruit development is dramatically altered, with a reduced fruit size [ 24].
