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Many data suggest that γδ T cells play a pathogenic role in CNS inflammation and autoimmunity [2], [13].
Third, contrary to our model, if phenotypes are organized in different modules (as many data suggest), their model will provide different estimates; in other words, their model requires that all traits can be simultaneously affected by a single mutations.
Many data suggest that this material has favorable properties.
While the exact molecular sequence is currently unknown, many data suggest a decreased synapse density [ 47] and a lower cholinergic tone [ 48] to be associated with the ApoE4 genotype.
However, many data suggest that the up-regulation of Foxc2, or its transfection, leads to an increase of cellular mobility often linked with progression, invasion and angiogensis of tumor [ 19, 20, 33].
In addition to its chaperoning function, many data suggest that GRP78 is a multifunctional protein and plays critical roles in the resistance to chemotherapy agents, proliferation, invasion, and metastasis of many human cancers [ 5– 9].
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Despite many data suggesting the pro-inflammatory action of adiponectin in joints [ 29, 74, 78], it cannot be completely excluded that high local and systemic levels of adiponectin help suppress inflammation in patients with RA.
Despite inadequate monitoring systems in many countries, data suggest that most of the H.I.V. epidemics in the Caribbean appear to have stabilized.
These and many other data suggest that complementary epithelial stromal coevolution is influential in cancer development.
In the case of EGFR and mTOR signalling pathways, many experimental data suggest that these pathways share overlapping signalling outputs (Adjei, 2006).
Many clinical data suggest that the inhibition of mTOR signalling decreases bone erosion in diseases such as rheumatoid arthritis, multiple myeloma or neurofibromatosis [ 12, 13].
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