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In doing so, miRNAs regulate many critical developmental processes, including cellular proliferation, differentiation, migration, and apoptosis, as well as more specialized biological functions such as dendritic spine development and synaptogenesis.
These binding sites form regulatory networks which determine the dynamics of many critical developmental and cellular processes.
This is supported by the recent discovery that cis-regulatory associations for many critical developmental regulators such as Grem have been conserved throughout animals (Irimia et al. 2012).
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While a host of additional genes are known to influence hair development, many play other critical developmental roles and would likely be lethal if function were perturbed [ 25].
The pro-apoptotic BH3-only protein, BIK, is widely expressed and although many critical functions in developmental or stress-induced death have been ascribed to this protein, mice lacking Bik display no overt abnormalities.
Many critical life changes occur during the developmental period of transition from childhood to adolescence.
Many of the genes that underlie critical developmental processes during metamorphosis, including sex-specific processes, have been identified.
In this nursery habitat a population of this animal might have found a more protected environment in which to spend critical developmental phases, as do many modern species today.
The transition from the vegetative mycelium to the primordium during fruiting body development is the most complex and critical developmental event in the life cycle of many basidiomycete fungi.
Exposure to environmental estrogens during critical developmental windows has well- documented adverse consequences on males and females of many species, including rodents and humans [ National Institutes of Health (NIH) 1999; Palmlund 1996].
Although miRNAs are involved in many processes, 60-70% of known plant miRNAs control the expression of transcription factors that regulate critical developmental processes, such as proper specification of floral organ identity or leaf polarity, and over-expression or knockout of MIRNA genes led to severe developmental defects [ 48, 54, 13].
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