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In the absence of such a measure, many (cost) effectiveness studies in obstetrics focus on specific aspects of labor, such as pain [ 4, 5], patient satisfaction [ 6], labor duration [ 7], or anxiety [ 8, 9].
8 32 In addition, the estimate of benefit in many cost effectiveness analyses is based on the outcome of an intention to treat analysis, but the estimated treatment cost assumes 100% adherence.
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Despite many cost-effectiveness analyses having been published important aspects remains under-researched, including the consideration of downstream effects (such as management of adenoma and CRC) linked to appropriate screening or follow-up tests.
Many cost-effectiveness analyses on rotavirus vaccination have been published for highly industrialised countries such as the UK [58], France [25, 59], Belgium [60], the Netherlands [61], Italy [62], and the US [63].
Many cost-effectiveness studies are flawed and industry funding appears to be an important source of bias [54].
Many cost-effectiveness studies assume that a single high viral load would automatically trigger a switch to the more expensive second-line regimen[9], [10], [33].
Many cost-effectiveness studies based on data from developed nations are irrelevant for developing nations.
Many cost-effectiveness analyses have been published [ 9- 17] with controversial results.
Many cost-effectiveness studies present data on the costs associated with a unit change in the main outcome of interest.
Although many cost-effectiveness (CE) analyses of diabetes interventions have been published, their qualities and conclusions vary.
As a result, most analyses considering health economics have concentrated on questions of which type of prosthesis to use, and many cost-effectiveness analyses have involved analysis of newer, more expensive operations against older, established comparators.
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