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SUM149PT cells are unable to regulate cyclin E and also exhibit many copy number alterations.
These experiments revealed many copy number differences that were previously associated with prostate cancer.
Many copy number variations (CNVs) exist on 22q11.2, some flanked by SDs.
Many copy number variants are of unknown significance; correlation and comparison with other patients will therefore be essential for interpretation.
However, they also share many copy number alterations and chromosomal rearrangements as well as deregulated therapy-responsive miRNAs and mRNAs.
In breast cancer, there are many copy number gains and losses, a few of which like amplification of ERBB2, are of known clinical and biological significance.
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This model can be used to provide more precise estimates for the chance of an abnormal phenotype for many copy-number variations encountered in the prenatal setting.
Many chromosome copy number errors are meiotic, and therefore will include three unmatched haplotypes.
The many genome copy number changes observed in SUM149PT cells may be directly associated with cyclin E overexpression.
All cell line-derived samples clearly shared many common copy number changes with the original tumor, such as gain of 6p.
In addition, comparative genomic hybridization indicated that SUM149PT cells exhibit many chromosome copy number alterations, which may reflect prior or ongoing genomic instability.
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