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Many compounds showing biological activities have also been listed in the literature from Penicillium sp. having no mutagenicity and cytotoxicity (Kaur et al. 2014; Arora and Chandra 2011).
We have seleted many compounds showing bactericidal activity.
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Many compounds showed moderate to good activities at the concentration of 10 μmol/L.
The preliminary SAR was discussed and many compounds showed potent Hh signaling inhibitory activities.
Many compounds showed balanced activity on both the receptors but compound (22) was found to be the most active derivative having higher antagonistic activity on both the receptors.
The antitumor activities against CCRF-HSB-2 and KB tumor cells have been investigated in vitro, and many compounds showed promising antitumor activities.
The antitumor activities against CCRF-HSB-2 and KB cells and the antiviral activities against HSV-1 and HSV-2 have been investigated in vitro, and many compounds showed promising antitumor activities.
The antitumor activities screening indicated that many compounds showed moderate to high levels of antitumor activities against these three cancer cell lines and most of these compounds displayed more potent inhibitory activities compared with commercial anticancer drug 5-fluorouracil (5-FU).
The antitumor activities screening indicated that many compounds showed moderate to high levels of inhibition activities against NCI-H460, HepG2, SK-OV-3, BEL-7404, HeLa and HCT-116 cancer cell lines and that some displayed more potent inhibitory activities than commercial anticancer drug 5-fluorouracil.
There are 5 periods at which many compounds show significant LD excess (CT 1 2, 7 8, 12 13, 15, 18) and 4 periods during which compounds show significant DD excess (CT 4 5, 10 11, 14, 16 17).
Many compounds showed potencies similar to EDTA.
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