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Interestingly, many compounds exhibited comparable VEGFR-2 inhibition to Sorafenib.
Many compounds exhibited high and broad-range bactericidal activity.
Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σ2.
The pharmacological screening results revealed that many compounds exhibited moderate to high levels of antitumor activities against the tested cancer cell lines and that most demonstrated more potent inhibitory activities compared with the commercial anticancer drug 5-FU.
While many compounds exhibited significant anticancer activity, compound 3a, was found to be the most promising analogue in this series with IC50 values of 3.1 μM on PC-3 cell line.
The screening results revealed that many compounds exhibited moderate to high levels of antitumor activities against the tested cancer cell lines and that most demonstrated more potent inhibitory activities compared with the commercial anticancer drug 5-fluorouracil.
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These scaffolds could be used for the design of many compounds exhibiting biological activities.
Variable cell growth inhibitory activities were obtained and many compounds exhibit potent %inhibition.
A physicochemical feature of the free sugar thioureido glycoconjugates was high water solubility (>20 mg/mL), as well many of these compounds exhibited a desirable potency and CA isozyme selectivity profile.
Many of these compounds exhibited nanomolar antiproliferation activities against human tumor lines in in vitro cell culture experiments, and a representative example (compound 26) demonstrated encouraging in vivo efficacy in a mouse xenograft tumor model derived from the A2780 cell line.
Many of these compounds exhibited insecticidal [1], antibacterial [3], epoxide hydrolase inhibitory [4], and cytotoxic [5] effects.
More suggestions(15)
many groups exhibited
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many circRNAs exhibited
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