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Third, many complexes are small (composed of two or three distinct proteins), so that traditional topological markers such as density are ineffective.

However, many complexes are only essential in the presence of some drug or stress, so many negative genetic interactions may only be observed under specific conditions.

Second, many complexes are embedded within highly-connected regions of the PPI network, which makes it difficult for clustering algorithms to accurately delimit their boundaries.

First, many complexes are sparsely connected in the PPI network, and cannot be picked out by clustering algorithms which search for dense subgraphs.

Third, many complexes are small (that is, composed of two or three proteins), making measures of important topological features, such as density, ineffectual.

First, many complexes are sparsely connected in the PPI network, and do not form dense clusters that can be derived by clustering algorithms.

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Similar(48)

In fact, the fraction of essential genes which are part of many complexes is not significantly higher than the fraction of inessential genes.

Many protein complexes are now known to involve the binding of linear motifs in one of the binding partners.

Many biological complexes are naturally low in abundance and pose a significant challenge to their structural and functional studies.

A truly non-innocent ligand Many nitrosyl complexes are not as straightforward.

Many asexual complexes are composed of hybridising sexual species and their asexual polyploid hybrids.

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