Sentence examples for many complex disease from inspiring English sources
However, the importance and role of target in many complex disease systems were not explicitly considered in the reported literatures about multi-target virtual screening.
As well as conferring susceptibility to recessive Mendelian diseases, ROH are also potentially an underappreciated risk factor for common complex diseases, given the evidence for a recessive component in many complex disease traits [18]; they will allow quantification of the risk arising from recessive genetic variants in different populations.
However, for many complex disease problems these conditions may not be satisfied.
Motivation: Many complex disease syndromes such as asthma consist of a large number of highly related, rather than independent, clinical phenotypes, raising a new technical challenge in identifying genetic variations associated simultaneously with correlated traits.
Furthermore, as in the case of many complex disease conditions, there is the promise that risk prediction profiles could be identified in which a number of genetic variants in the aggregate can help assess risk [ 23].
Motivation: As many complex disease and expression phenotypes are the outcome of intricate perturbation of molecular networks underlying gene regulation resulted from interdependent genome variations, association mapping of causal QTLs or expression quantitative trait loci must consider both additive and epistatic effects of multiple candidate genotypes.
The discovery, considered a major medical and scientific breakthrough, has enormous implications for human health because many complex diseases appear to be caused by tiny changes in hundreds of gene switches.
Nicolson and others believe that as with so many complex diseases, CFS is really an umbrella term for a whole variety of underlying illnesses – some psychological or due to anxiety-related exercise intolerance, but many others down to neurological impairment, energy-production impairment or even autoimmune dysfunction.
The machine could help unravel the genetic basis of many complex diseases, including diabetes, Alzheimer's disease, and some cancers.
The occurrence and development of many complex diseases are associated with various molecules, whose contents are rarely in the early stage of the disease.
They are influenced by environmental exposure, life-style, and aging and have recently been shown to be altered in many complex diseases including inflammatory diseases.
