Sentence examples for many clock genes from inspiring English sources

Direct comparison of differentially expressed genes between 'trough' and 'peak' BP samples would normally identify many "clock" genes that are of limited interest.

Intriguingly, the mutant mouse models of many clock genes, such as Arntl, Clock, Npas2, Cry1 and Cry2, also have alterations in sleep duration and homeostasis [52], [53], [54], [55].

Many clock genes in mouse, fish and chick are Notch targets.

However, in prolonged darkness, the expression profile of many clock genes was dramatically damped.

Many clock gene products function as transcription factors, which possess PAS (PER, ARNT, SIM) and basic helix-loop-helix (bHLH) domains involved in protein-protein and protein-DNA interactions, respectively.

This is to be expected based simply on the many clock regulated genes reported to date, the possibility that a single miRNA can target many different transcripts and the use of multiple prediction programs.

The level of nuclear CLK, transcriptional activator of many core clock genes, is also reduced in shits1 flies, and Clk overexpression suppresses the period-altering effects of shits1.

Unlike many core clock genes, Zfhx3 is not ubiquitously expressed, so any cell-autonomous influence would be limited to regions where it is expressed, such as the SCN.

The expression of many miRNAs is found to be rhythmic, not only in liver but also in retina and SCN, and bioinformatics, as well as experimental evidence, suggests that many core clock genes are under the control of miRNA.

Recently, a genomic-scale chromatin immunoprecipitation assay revealed that TOC1 binds to and represses not only CCA1 and LHY but also many other clock genes, such as PRR9, PRR7, TOC1, GI, LUX, and ELF4(25).

The late 1990s to early 2000s was a time of great advancement in circadian biology, with the discovery of many core clock genes and the unraveling of the core circadian mechanism as an interlocking transcription translation feedback loop.