Many clinical tests of fitness are based on resting pulse rates, response to exercise and return after exercise.
Most of the time, clinical examination can orientate towards an articular or periarticular pathology, but it cannot identify the precise topography or the pathological mechanism, even if there are many clinical tests [18].
We next set out to build a system of ligand-encoded reporters that would allow quantification of protease activity in a 96-well format by ELISA, the primary detection platform for many clinical tests.
Many clinical trials testing various AD targets have been carried out but, unfortunately, have been considered failures since the test treatment did not prevent or slow cognitive decline (for review, see Rafii & Aisen, 2009).
During the past decades, many clinical trials testing anti-inflammatory therapies have been performed.
As a consequence, throughout the last two decades many clinical trials testing systemic agents for patients with malignant mesothelioma did not distinguish between those with the pleural versus the peritoneal form of disease.
This increased mechanosensitivity is the key characteristic that is being evaluated in many clinical provocation tests, such as Spurling's test for cervical radiculopathy and the straight leg raising test for lumbar radiculopathy [ 11, 12].
Many clinical mobility tests have been used for individuals who have suffered a stroke; however, the ceiling effect has been identified as a limitation for relatively high functioning individuals.
Many clinical laboratory tests have likelihood ratios of 10 or more.
Or so, on the basis of many ingenious clinical tests, the sober mind of science implacably perceives.
