Sentence examples for many client proteins from inspiring English sources

Many client proteins of Hsp90 are involved in tumor progression and survival and therefore Hsp90 can be a good target for developing anticancer drugs.

Hsp90 is part of the class of molecular chaperone proteins that plays a central role in the assembly of multi-protein chaperone complexes and regulates folding, stability and function of many client proteins that are oncogenic drivers of lung adenocarcinoma subsets such as mutant EGFR, wild-type CRAF, mutant BRAF, wild-type and mutant HER2, and EML4-ALK fusion protein positive NSCLC.

Consequently, many client proteins are targeted for degradation via the ubiquitin-proteasome pathway.

Cancer cells contain elevated levels of active Hsp90 [25] and, because many client proteins play critical oncogenic roles, cancer cells are particularly sensitive to Hsp90 inhibition.

Many client proteins of Hsp90 are oncogenes that depend on permanent chaperone support.

The molecular chaperone Hsp90 is important for the functional maturation of many client proteins, and inhibitors are in clinical trials for multiple indications in cancer.

Many oncogenic client proteins involved in formation of metastatic pathways.

Many Hsp27 client proteins have been reported previously [ 27].

Inhibition of HSP90 results in the proteosomal degradation of many HSP90 client proteins.

One of these proteins, Cdc37, co-chaperones for many kinase client proteins including Erb-B2, c-Raf, CDK4, CDK6 and Akt [ 72].

Correct protein folding of many ER client proteins relies on N-linked glycosylation and exposure to the glycosylation inhibitor tunicamycin leads to increased protein misfolding and ER stress (28).