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And many centres have been forced to target services at families with very complex needs.

Kidney-graft survival has improved since the introduction of the immunosuppressive agent cyclosporine (also called cyclosporin A; see below), and many centres have achieved a one-year survival rate of 80 percent and a two-year rate of 70 percent for patients with a functioning kidney graft from an unrelated cadaver donor.

Many centres have higher staffing ratios than the regulated standards.

Many centres have reported positively on their clinical experiences as reviewed recently by Fagnoul et al. [8].

Flexi hours within the 12 hours a day is available but not many centres have extended hours.

There has also been a major evolution in chest CT, now that many centres have modern multidetector CT.

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Many centres had no television, and no lessons or activities for the children.

Many centres had no control over equal access.

By the end of the study period, many centres had changed from using Hickman lines in the delivery of the Lokich regimen, to cheaper peripherally implanted central catheters.

By the time they were asked to distribute recruitment packs, many centres had archived their 4-T files and any loyalty they may have had towards 4-T is likely to have been supplanted by newer research studies.

Diabetes management in many centres has been based on conventional self-monitoring of plasma glucose concentration (SMPG) for several years [ 12– 16] or even on continuous glucose monitoring (CGM) [ 17– 20] resulting in a downward trend in all diabetes complications, especially in individuals with type 1 diabetes [ 8– 10].

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