Sentence examples for many cellular substrates from inspiring English sources

Folding of many cellular substrates of TRiC cannot be assisted by any other chaperone.

The serine protease, a high temperature requirement protein A2 (HTRA2), cleaved many cellular substrates including cytoskeletal proteins as well [ 9].

Indeed, the maximal tyrosine phosphorylation of many cellular substrates, such as paxillin, requires both Src and FAK activity [ 6].

They are synthesised as zymogens (procaspases) that are activated by proteolytic cleavage and can cleave many cellular substrates in regulating apoptosis [ 24].

Active caspase-8 can then, either directly, or indirectly via the BH3-only protein Bid, activate effector caspases, such as caspase-3, which in turn cleave many cellular substrates resulting in the biochemical and morphological features characteristic of apoptosis [ 11].

Especially of interest is the fact that protein kinase C (PKC), a family of serine/threonine kinases, has the potential to activate many cellular substrates in vitro and yet only discrete pathways are activated in the cell.

We have previously demonstrated that FN is the main Q-donor substrate in osteoblast matrix and accumulates in large quantities in the cells [16], however, many other cellular substrates may exist [27], [28].

Cooperative binding of two cAMP molecules to each R subunit causes the release of active C subunit [2] and leads to downstream cellular changes in the activity of transcription factors, enzymes, ion channels, and many other cellular substrates [3], [4].

Caspase-3 is one of the most important executioner caspases, and it is capable of cleaving many important cellular substrates such as PARP [ 35].

Once bound, Src can phosphorylate FAK on several residues including Y925 resulting in the further activation of FAK tyrosine kinase activity [ 3] and in the phosphorylation of many other cellular substrates.

Once initiated, caspase-9 can go on to activate effector caspases such as caspase-3 and −7, which then cleave many important cellular substrates and causes cell death [ 5, 34, 35].