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One of many cellular models to study EMT is the EpH4/EpRas cell system.
NF- κB has been postulated, in many cellular models, to be the main regulator of the antiapoptotic response triggered by TNFR1 activation.
On the other hand, it is well known that the UPR has been linked to several inflammatory response pathways in many cellular models and diseases.
In many cellular models, including the neuronal cell model PC12, it has been demonstrated that inhibition of protein synthesis is sufficient to render cells sensitive to apoptosis induced by TNF α.
ERK activity has also been associated with autophagy and autophagic cell death in many cellular models in response to different stresses [ 13] and also in TNF- α (tumor necrosis factor-alpha) treatment in MCF-7 cells.
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Loss expression of p21 has been linked to drug-resistance in many in vitro cellular models.
It has been reported that genetic and epigenetic abnormalities can induce lower expression of p21, which is linked to chemoresistance in many in vitro cellular models [ 18].
Absence of p21WAF1/CIP1, a cyclin-dependent kinase (cdk) inhibitor, has been linked to drug resistance in many in vitro cellular models.
Certain simple filament shapes have been observed with various cellular models (many noncardiac).
Approximately 20% of familial cases are caused by mutations in the gene coding for Cu/Zn superoxide dismutase (SOD1), and following linkage studies published in 1993, many different transgenic animal and cellular models of human SOD1 mutations have been developed, increasing our knowledge about the pathogenesis of both sporadic and familial forms of ALS [2].
Murine models have provided many cellular and molecular insights into brucellosis pathogenesis, such as the efficacy of vaccine candidates, nature of major virulence factors, and essential host immune responses (Baldwin and Goenka, 2006; Murphy et al., 2001).
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many black models
many cellular responses
many cellular pathways
many cellular events
many cellular components
many cellular proteins
many cellular substrates
many cellular processes
many prognostic models
many cellular factors
many diverse models
many different models
many cellular transformations
many cellular conditions
many cellular functions
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