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Protein kinase C (PKC) is a family of kinases that are critical in many cellular events.
As these DRM microdomains are involved in many cellular events, an imbalance or disruption of the cell membrane homeostasis may impair normal cell function.
Accumulating abnormalities in glucose/lactate balance in combination with accelerated mitochondrial damage in neurons may be at the core of many cellular events in senescence and neurodegeneration, including the initiation and progression of LOAD15.
Signaling via JNKs, also known as stress-activated MAP kinases, is activated by cytokines such as TNF-α or by stress stimuli, including ultraviolet irradiation, redox stress, and osmotic stress39,40; JNK signaling activation plays a crucial role in the control of many cellular events, such as growth and apoptosis41.
JNK is also activated during many cellular events, such as growth control, transformation, and apoptosis [43 45].
Endocytosis is involved in the regulation of many cellular events, including signalling, cell migration, and cell polarity.
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Protein tyrosine phosphorylation plays essential roles in many cellular physiological events, such as cell growth, division, differentiation, adhesion, motility, and death [1].
The hemorrhage phase of the injury forms a lattice for many following cellular events.
DNA duplex formation by annealing or hybridization of two complementary single strands is a central reaction in many important cellular events and such fundamental biological processes as replication, transcription, and recombination.
The binding of insulin or IGF-1 to the membrane receptors leads to the activation of the PI 3-kinase/Akt signaling pathway and subsequent downstream events such as phosphorylation of FOXO1 and activation of the mTORC1 signaling pathway, which regulate many important cellular events such as mRNA translation, protein synthesis, cell cycle progression, metabolism, and aging.
Prior to the present study, the involvement of DSS1 protein in many critical cellular events and processes has been illustrated, but its role as a modifier attached to the proteins of interest in cells under oxidative stress has not previously been demonstrated.
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