Sentence examples for many cellular effects from inspiring English sources
The cNef region falls in the "central conserved region" and includes the second alpha helix (key for interaction with the src kinase SH3) and the three adjacent beta strands that compose the central structured core domain [29], and thus contains a key binding site required for many cellular effects of Nef, and sequences that are a crucial structural scaffold.
Although many cellular effects of oxidized phospholipids are mediated by receptors it is unlikely that specific receptor binding is the only primary event responsible for lipid activity.
aSyn dysfunction has been associated with many cellular effects, including proteasome impairment, disruption of endoplasmic reticulum-to-Golgi trafficking, increased production of reactive oxygen species (ROS) and mitochondrial dysfunction.
Antioxidants elicit many cellular effects that are unrelated to ROS-quenching per se [ 25, 26], and it is undoubtedly naive to think that other pathways and processes are not affected following supplementation.
Two of the many cellular effects of insulin are to promote F-actin stress fibre disassembly and to induce the trafficking of GLUT4 transporters to the plasma membrane (Ikonomov et al., 2002).
Examples of duodenal tissue damage are shown in Figure 4A and B. Vacuolization can be indicative of many cellular effects such as altered lipid metabolism, sequestration of absorbed material, autophagy, endoplasmic reticulum (ER) stress or proteasome dysfunction (Franco & Cidlowski, 2009; Henics & Wheatley, 1999; Mimnaugh et al., 2006).
It will be interesting to determine if this is a common property of nanomaterials or if this is influenced by size, shape and charge as with many other cellular effects of nanomaterials.
Many of these cellular effects are mediated by a group of seven transmembrane G-protein-coupled receptors, uniquely activated by proteolytic cleavage [protease-activated receptors (PARs)].
Perhaps the most established are the TEAD1-4 (TEA domain family member) transcription factors (orthologs of Drosophila Sd), which have been shown to mediate many of the cellular effects of activated Yap/TAZ [17],[17]-[17].
Many of the cellular effects of AnxA1 are mediated by a specific G-protein-coupled 7-transmembrane receptor, termed ALX.
On a cautionary note, many cellular and physiological effects of PAR2 activation have been implicated solely through the use of PAR2 peptide agonists (e.g. SLIGKV-NH2, SLIGRL-NH2, 2-furoyl-LIGRLO-NH2) now known to be non-selective for PAR2 over other targets, even though selective over PAR1.
