Sentence examples for many cellular contexts from inspiring English sources

In the past decade, much work has been done to develop targeted inhibitors of HDACs, since they are now established oncogenes in many cellular contexts.

ATF4 regulates genes involved in metabolism and nutrient uptake and was shown to have a cytoprotective role upon stress in many cellular contexts (Ye et al., 2010).

Around a half of the surveyed pairs had their SRs >50%, suggesting these pairs were transcriptionally correlated in many cellular contexts.

DRFs have been shown to play critical roles in the formation of diverse actin-based structures in many cellular contexts, including cytokinesis, cell adhesion, polarized cell growth and cell migration (Faix and Grosse, 2006).

The ability of these algorithms to accurately predict developmental enhancers based on data from related, but distinct, cellular contexts suggests that combining computational models with epigenetic data sampled from relevant contexts may be sufficient to enable functional characterization of many cellular contexts of interest.

This is important in many cellular contexts including neuronal dendrites (Kindler and Kreienkamp, 2012), oocytes and early embryos (Lasko, 2009), and even in single-celled eukaryotes, such as the budding yeast, where controls over ASH1 mRNA localization and translation establish the specificity of mating type switching (Paquin and Chartrand, 2008).

Actomyosin networks generate force in many different cellular contexts, so it is reasonable to suspect that they might also be involved in IKNM.

β-Catenin is an evolutionarily conserved protein that is relevant in many different cellular contexts, including vital ones in the human central nervous system.

DOI: http://dx.doi.org/10.7554/eLife.09206.002 In many developmental and cellular contexts, actin filaments construct complex and highly dynamic structures to accomplish cell shape changes such as in migration and cytokinesis (Munjal and Lecuit, 2014).

As NF-κB activation can induce or repress the expression of many genes in different cellular contexts (Hoffmann et al., 2006), it remains unclear whether NF-κB mediated growth inhibition is brought about by repression of those genes involved in the promotion of growth or the induction of genes that can in turn negatively regulate growth.

One example of such a domain is the PDZ domain of PSD-95, which is involved in interactions between many different proteins in a variety of cellular contexts.