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Many cells undergo programmed cell death, or apoptosis, during fetal development.
This may indicate that many cells undergo cell death, which may take up to 24 h.
When the ovary is destroyed by CTX, many cells undergo apoptosis.
It has been appreciated for some time that primary RPE cells, like many cells, undergo a permanent switch in phenotype with repeated passage [ 30].
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The terminal deoxynucleotidyl transferase-mediated dUPT nick end labeling assay demonstrated many cells undergoing apoptosis.
Implantation induces an inflammatory response because of invasion and damage of maternal tissue, with many cells undergoing apoptosis (Jerzak and Bischof, 2002; Joswig et al., 2003).
Multiple lineages of hematopoietic cells as well as many leukemic cells undergo apoptosis and growth arrest in the absence of IL-3.
Many cancer cells undergo epithelial-mesenchymal transition (EMT) to achieve enhanced motility and to gain resistance to apoptosis; however, some cancer cells might undergo collective migration independent of an EMT program.
Given this, it will be critical to determine exactly which cells of the human body are telomerase-positive, when and how telomerase is silenced upon differentiation, and how many divisions cells undergo in human tissue after becoming telomerase-negative.
During embryonic development, many epicardial cells undergo an epithelial-to-mesenchymal transition (EMT) and migrate into the deeper layers of the myocardium to form the stromal cells of the heart, including cardiac fibroblasts and caSMCs.
The E-selectin-based approach also allows to capture cells using those surface markers with low-level expression, which is particularly important, given that many tumor cells undergo phenotypic changes in terms of surface marker expression upon EMT and yet such metastatic/post-EMT cells still highly express E-selectin ligands.
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