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Bcl-2 blocks or delays apoptosis in many cell systems.
By managing the competing effects of ice formation and solute composition changes on the cell through the use of carefully choreographed cryoprotectant addition/removal and cooling/thawing processes, successful protocols have been developed for many cell systems.
Exploiting this compartmentalization of substrates, we specifically target the endosomal β-secretase by an endosomally targeted β-secretase inhibitor, which blocked cleavage of APP but not non-amyloid substrates in many cell systems, including induced pluripotent stem cell (iPSC -derived neurons.
The role of two cysteine proteases; caspase and calpain has been highly implicated in programmed cell death in many cell systems [12], [13].
While these reported discrepancies regarding cortactin function in lamellipodia have yet to be fully reconciled, it is clear that cortactin is an important regulator for normal and tumor cell migration in many cell systems [11], [23].
These studies demonstrate the wide importance for the mTOR complexes in many cell systems.
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HIF is a transcription factor protected from degradation in many cell system under hypoxic conditions.
Receptor endocytosis plays crucial roles in coordinating the strength and duration of many cell signaling systems (Piddini and Vincent, 2003; Polo and Di Fiore, 2006).
However, addressing the functional significance of adhesion molecules in stem cell orientation has been challenging in many stem cell systems including Drosophila male GSCs, since these molecules are essential for the maintenance of stem cells within the niche.
Compared with many other cell systems, malignant conversion of these cells occurs with relative ease.
In many other cell systems, co-participation or complementary roles for the two STIM proteins have been postulated [ 15, 48].
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