In many cases, a genome encodes a single lanthipeptide synthetase, but a large number of substrates.
Notwithstanding, many cases of genome reorganization (e.g., rearrangement, duplication and loss) occur in closely related animals [ 2– 4].
In many cases, personal genome assembly is also complicated by sample heterogeneity, such as tumor samples with subpopulations of somatically-acquired variants that are present in only a subset of the sequencing data.
The delineation of intraspecific evolution of RCCX CNV mainly relied on haplotypic information obtained by a set of ASLR-PCRs, which enabled us to haplotype RCCX CNV alleles and structures in many cases that genome-wide platforms for CNV discovery have not yet resolved (Alkan et al. 2011).
The complete probe set used for microarray analysis contained all annotated genes for nitrogen metabolism for each included genome, and in many cases, genes from both nitrate assimilation and dissimilatory nitrate/nitrite reduction pathways were present in the same organism.
In many cases, a stable genome structure consisting of many synteny blocks, called "genomic core," is shared by many genomes.
As re-sequencing the genome of large numbers of samples is still cost-prohibitive in many cases, methods for genome complexity reduction have been developed in attempts to capture most ecologically-relevant genetic variation.
However, the application of profile-based search methods to the detection of TE-derived sequences among well-curated experimentally characterized protein data sets did not turn up many more cases than had been previously detected and nowhere near as many cases as recent genome-wide searches have.
Although genes and, in many cases, multigene regions of genomes possess elaborate architectures that ensure regulation of expression, these arrangements are evolutionarily volatile and typically change substantially even on short evolutionary scales when gene sequences diverge minimally.
In many cases, however, the virus genome is not easy to search for particular mutations because recovery of complete viral sequences from clinical specimens remains extremely difficult.
