For example, the recent Presidential primary season witnessed pledges from many candidates not only to improve health care but also to save money by spending more on prevention (2).
Among many additional candidates, only one, insulin-like growth factor binding protein 3 (IGFBP3), was downregulated in both human and mouse models and co-expressed in hypocretin neurons.
Genetic studies (in particular linkage and association studies) identify chromosomal regions involved in a disease or phenotype of interest, but those regions often contain many candidate genes, only a few of which can be followed-up for biological validation.
Many parentage studies suffer from incomplete sampling of potential extrapair sires, or the genotyping system (e.g., multilocus minisatellite fingerprinting or too few microsatellite markers) is not very powerful in detecting the true sire among many candidates and can only be used for paternity exclusion purposes.
In contrast to many candidate-gene approaches, only one recently published study analysed 80 men with normozoospermia, 52 with OAT, and 40 with non-obstructive azoospermia (histology not mentioned) using whole genome SNP arrays [27].
However, retrocopy screening based on proteins (used by Zhang) usually revels only half as many candidates.
Thus, although we found many candidates fulfilling the miRNAs structural criteria, we retained only those that we could detect by Northern and whose expression is dependent on OsDCL1.
While many candidates, including myself, would like to be in the presidential debates, there's only one candidate who is truly qualified and has strong polling numbers warranting inclusion: Libertarian presidential candidate Gary Johnson.
In 2014, the festival selected only half as many shorts out of more than twice as many candidates.
Among many candidate predictors we found only relatively high age, living alone and high triglycerides to be associated with worsening of visual acuity over 6 years, while high age, living alone, low self-rated health, and low level of physical activity were associated with a low level of visual acuity.
