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In contrast, the many candidate gene studies of ADHD have produced substantial evidence implicating several genes in the etiology of the disorder.
While genome wide association studies (GWAS) have shed new light on the types of genes involved in migraine susceptibility, many candidate gene association studies have focused on neurotransmitter-related pathways, as these pathways are considered to play a significant role in the migraine process.
Despite many candidate gene studies in PCOS, few biologically selected candidates have been replicated.
Furthermore, many candidate gene studies were performed in the post GWAS era, by deep sequencing around GWAS loci.
The widespread inconsistency reported in many candidate gene studies [23], [24] has variously been attributed to factors such as epistasis, population drift, population stratification, and genetic diversity.
Many candidate gene association studies have been performed over the past 40 years, but the results have been largely inconsistent.
Similar(47)
Many candidate genes are out there.
The SHL QTLs contained many candidate genes.
Many candidate genes are now thought to confer susceptibility to autism spectrum disorders (ASDs).
However, too many candidate genes were identified in that study, and much more experimental evidence was needed to better verify the roles of the screened genes.
The drawback is that the resolution power of GWAS should be limited as many candidate genes may be detected in a same LD block (Yano et al. 2016).
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