Diets high in fruits and vegetables demonstrate a strong and consistent pattern for decreasing the risk for many cancers and providing benefits against cardiovascular disease, diabetes, obesity, and stroke.
Most notable, the identification of p53 tumor suppressor gene pathway in medulloblastoma transcription factor interactomes is consistent with known p53 upstream and downstream mutations in many cancers, a central mechanism in the mutagenesis of cancer cells.
This is consistent with the observation that serum HGF was elevated in many cancers (Christensen et al, 2005).
Consistent with such a function, overexpression of Pin1 has been observed in many cancers, and its levels are predictive of cancer recurrence [10], [11].
Consistent with this, a higher Ang2 Ang1 ratio correlates with worse prognosis for many cancers (36).
The differences in the completeness index are consistent with the improvements in survival observed between 1992 and 2004 for many cancers (Cancer Research UK, 2007; Rachet et al, 2008).
Consistent with its tumor suppressor role, Par-4 is shown to be downregulated in many cancers.
Consistent with this observation, an increased expression of various Id isoforms has been detected in many cancers [ 24- 32].
Strong and consistent epidemiological evidence also indicates that a diet rich in antioxidants significantly reduces the risk of many cancers [ 31].
Strong and consistent epidemiological evidences suggest that a diet enriched with naturally occurring substances significantly reduces the risk for many cancers.
