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There are many bxd mutations caused by chromosome breaks.
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This was supported by some of the early work using bxd mutations.
However, many of the mutations in the Mutation database concern germline mutations identified in VHL-families.
The IDH-2 mutation is just one of many enzyme mutations that are found in acute myelogenous leukemia.
The defect results from one of many possible mutations in a very large gene.
There are many serious mutations among insects due to the absence of public conveniences.
Many such mutations increased in frequency by natural selection until all members of the species had them.
Interestingly, many Pax6 mutations that cause eye developmental defects have mutations that disrupt the PD (van Heyningen and Williamson, 2002).
Recent discoveries include many novel mutations in the hemiplegic migraine gene ATP1A2.
Since rice transformation induces many somaclonal mutations, such a control is inappropriate.
Notably, recently, many new mutations have been identified in both MLL2 and MLL3, showing diversity of both mutation and tumor type.
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