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On a molecular level, lead binds to many proteins, especially to thiol and carboxyl groups, and mimics calcium in many biologic pathways (Goldstein and Ar 1983; Kern et al. 2000; Rabinowitz 1991; Rabinowitz et al. 1973).
Differences in stem cell biology, bone marrow microenvironment, or signaling pathways could exist since many biologic pathways are triggered by BCR-ABL and are successfully inhibited by TKI therapy [ 45– 47] but data to support this in AYAs are still lacking.
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Although genomic comparison showed that in G. lamblia the contents of many fundamental biologic pathways are simplified and the whole genome is very compact, in our study 40% of its genes were identified as duplicated genes.
Consistent with miRNAs functioning to regulate a variety of biologic pathways, many different miRNAs have been shown to promote the iPSC generation through overcoming different barriers toward reprogramming.
However, owing to the common biologic pathways of many cytokines, we chose to combine markers into a composite score, which could strengthen a single measure with multiple possible pathways.
Many of the new anti-cancer medications target specific biologic pathways and are expected to cause less adverse effects on healthy tissues.
They are recognized by glycan-binding proteins with lectin activity on apposing cells, and such glycan-ligand interactions mediate many biologic activities including recognition of pathogens and induction of intracellular signaling pathways.
Many model organisms are not as genetically diverse as are humans but have orthologous genes and biologic pathways that are represented in humans.
As a result, many novel loci have been identified; the exploration of the genes within these loci should provide information about which genes and biologic pathways are associated with complex diseases.
We have developed a portfolio of antibodies that target biologic pathways critical for survival of tumor-initiating cells, with the goal being to stop those cells from replicating.
Advances in microscopy have contributed to many biologic discoveries.
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