Sentence examples for many binding sites from inspiring English sources
* There continues to be a misguided insistence on the assumption that binding PRC1 automatically compacts chromatin, although in ES cells it is clear that many binding sites are the typical bivalent sites that also have methylated H3K4 and bind RNA polymerase.
Many binding sites were found to shift dramatically between embryos and starved larvae, from developmentally regulated genes to genes involved in metabolism.
That, to return briefly to the farmyard, depends on both the size of the haystack (that is, on the size of the genome ie, how much DNA there is to sort through) and on the number of needles (that is, on how many binding sites for one particular type of protein there are).
We identified many binding sites for the histone methyltransferase G9a (see Supplementary Figure S1 for examples of G9a peaks).
The regulation of the erythropoietin (Epo) gene was analysed, which exhibits many binding sites for circadian regulators.
The top 1% cutoff was used for KAP1 and SetDB1 experiments, and the top.5% cutoff was used for G9a to eliminate false positives since this factor does not have many binding sites.
Conversely, it may simply indicate that our definition of the motifs is too restricted (in order to minimize false positives) and that many binding site locations remain unidentified in this analysis.
The side chain RMSF and standard deviation of ΔASAs give similar indications for many binding site residues, where residues used inconsistently across multiple complexes are the most likely to undergo conformational rearrangement.
It is expected that one 3'UTR contains many miRNA binding sites and one miRNA might target many 3'UTRs.
This is of special relevance as FN has many cryptic binding sites which can be unmasked and exposed by sGAG binding31,44,51.
One possibility is that the transition of olfactory-receptor genes from a repressed, heterochromatic state to an active state requires many LHX2 binding sites to ensure that enough chromatin-remodelling proteins, which are necessary for this transition, are recruited.
