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Many binding sequences related to various functions occurred at low frequency and were not significant.
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Many TF binding sequences are relatively short and non-unique and hence, the expected number of their occurrences in a genome by chance is high.
However, many of their binding sequences are also distinct (the TF spheres appear not to overlap completely).
This was absolutely unexpected because many SeqA-bound DNA-regions detected in this experiment did not contain many of the established GATC binding sequences.
However, Wade et al. note that for many of the DSTs no such typical binding sequences could be found [ 7].
We found evidence for a DAF-16 binding sequence upstream of many of these genes, suggesting that DAF-16 may co-ordinately control these changes in gene expression.
When analyzing the binding sequence, we found that many direct repeat, inverted repeat, or direct complement sequence motifs existed within these p7 DNA substrates (Fig. 3D).
We found at the very beginning of the core sequence a high score half-ERE, followed in many cases by other instances of the same binding sequence.
Many enzymes that catalyze post-translational modifications recognize a specific binding sequence on the substrate.
Many prediction algorithms take into account the conservation of the microRNA binding sequence in the mRNA target.
A consensus DosR binding sequence has been identified in the upstream regions of many genes from the DosR regulon [22], [25].
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